
GS 441524 triphosphate
CAS No. 1191237-69-0
GS 441524 triphosphate ( —— )
产品货号. M20633 CAS No. 1191237-69-0
GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,感染病毒的原代人肺和猫细胞的细胞模型中显示出相似的活性。 GS-441524 对猫传染性腹膜炎病毒 (FIPV) 有较强的抑制作用,对应的 EC50 值为 0.78 μM。
纯度: >98% (HPLC)






规格 | 价格/人民币 | 库存 | 数量 |
50MG | ¥470 | 有现货 |
![]() ![]() |
100MG | ¥770 | 有现货 |
![]() ![]() |
200MG | 获取报价 | 有现货 |
![]() ![]() |
500MG | 获取报价 | 有现货 |
![]() ![]() |
1G | 获取报价 | 有现货 |
![]() ![]() |
生物学信息
-
产品名称GS 441524 triphosphate
-
注意事项本公司产品仅用于科研实验,不得用于人体或动物的临床与诊断
-
产品简述GS-441524 是 Remdesivir 的主要活性代谢物,活性更优于 Remdesivir ,感染病毒的原代人肺和猫细胞的细胞模型中显示出相似的活性。 GS-441524 对猫传染性腹膜炎病毒 (FIPV) 有较强的抑制作用,对应的 EC50 值为 0.78 μM。
-
产品描述GS-441524 treatment of cats with naturally occurring feline infectious peritonitis.
-
体外实验The cells appear and grow normally at all concentrations of GS-441524 and fail to uptake the fluorescent dye CellTox Green at 24 h. The cytotoxic concentration-50% (CC50) is therefore>100 μM. The effective concentration-50% (EC50) of GS-441524 is calculated to be 0.78 μM.
-
体内实验All 10 treated cats have a rapid response to treatment and lymphocyte levels and rectal temperatures return to pre-infection levels and levels of the two asymptomatic cats. All ten of the once or twice treated cats have remained normal to date (more than eight months post infection). Injections cause a transient "stinging" reaction in some cats within 10 s of compound administration. Localized and transient pain is evidenced by unusual posturing, licking at the injection site and/or vocalizations that last for approximately 30-60 s after injection. Injection reactions are more pronounced in some animals relative to others and reactions are inconsistent from one injection to the next and decreas over time.Remdesivi (IV injection) in NHP results in GS-441524 being present in serum at concentrations 1000-fold higher than Remdesivir throughout a 7-day treatment course.
-
同义词——
-
通路Others
-
靶点Other Targets
-
受体Others
-
研究领域——
-
适应症——
化学信息
-
CAS Number1191237-69-0
-
分子量291.26
-
分子式C12H13N5O4
-
纯度>98% (HPLC)
-
溶解度In Vitro:?DMSO : 83.33 mg/mL (286.10 mM)
-
SMILESNc1ncnn2c(ccc12)[C@@]1(O[C@H](CO)[C@@H](O)[C@H]1O)C#N
-
化学全称(2R3R4S5R)-2-(4-aminopyrrolo[21-f][124]triazin-7-yl)-34-dihydroxy-5-(hydroxymethyl)tetrahydrofuran-2-carbonitrile
运输与储存
-
储存条件(-20℃)
-
运输条件With Ice Pack
-
稳定性≥ 2 years
参考文献
1.Pedersen N C Perron M Bannasch M et al. Efficacy and safety of the nucleoside analog GS-441524 for treatment of cats with naturally occurring feline infectious peritonitis[J]. Journal of Feline Medicine & Surgery 2019.
产品手册




关联产品
-
Ophiogenin 3-O-α-L-r...
Ophiogenin 3-O-α-L-rhamnopyranosyl-(1→2)-β-D-glucopyranoside 是一种天然产物,对心血管系统具有良好的药理作用。
-
Sulfamethoxazole sod...
磺胺甲恶唑钠是一种磺酰胺类抑菌抗生素。
-
Thalidomide-NH-CH2-C...
Thalidomide-NH-CH2-COOH 是一种合成的 E3 连接酶配体-接头缀合物,含有基于 Thalidomide 的 cereblon 配体和接头。